A human genomics community

VarSome's mission is to bring together the global life sciences community and facilitate the exchange of information that will lead to new discoveries. To support the community, we at Saphetor, have contributed a search engine and knowledge base for human genomics.

A large continuously updated data library

So far, we have accumulated about 50 billion items of variant and gene annotation and have made it easily accessible, so you will quickly get what you are looking for.

We hope you find VarSome useful. If we have forgotten something, please let us know. We welcome your feedback! (confidential feedback form at the bottom of the page).

VarSome is free!

For research use only. We strive to include as much data and features as possible - this is our commitment to the life sciences research community.

Link to VarSome

You can link to VarSome from your internal or public website, even your Excel sheet. Instructions.

Cite VarSome

If you use VarSome in your research, please remember to cite our publication:

Christos Kopanos, Vasilis Tsiolkas, Alexandros Kouris, Charles E Chapple, Monica Albarca Aguilera, Richard Meyer, Andreas Massouras; VarSome: the human genomic variant search engineBioinformatics, , bty897, https://doi.org/10.1093/bioinformatics/bty897

A RESTful API for your own applications

VarSome is built on top of our REST API infrastructure that can also be used by institutions wishing to annotate their data at a fraction of the cost of discovering and gathering variant information from different databases across the Internet. Click here for more information.

VarSome in your premises

Both VarSome and the variant API behind it can be installed and maintainted within the infrastructure of organisations. If you are interested, contact us.

Important note for lecturers / course coordinators

We are honored that VarSome is increasingly being used in lectures, seminars and presentations. Please contact us if you are planning to give a course or lecture featuring VarSome, so we can white-list your IP address. This will ensure that you are not affected by usage limits for unregistered users during the session.


Multiple databases

VarSome contains data from various public databases including dbSNP, ClinVar, gnomAD, RefSeq, Ensembl, dbNSFP, Gerp, Kaviar, CIViC  and more...

Flexible queries

You can input your query in a large range of formats, including genomic position, HGVS DNA level and HGVS protein level. You can also query for a specific gene symbol.

Equivalent indels

For indels with several equivalent representations, we display the alternative ways that these indels may be defined. Also, data from the public databases VarSome integrates are normalized to take into account these equivalent representations.

Functional variant annotation

All variants are functionally annotated relative to genes and transcripts, whether they are found in any of these public databases or not.

Nearby variants

For every variant query, VarSome displays nearby variants from some of the public databases with key information from each and a link to the results page for each individual nearby variant.

A strong community

You can provide comments and opinions on the pathogenicity of variants, sharing them with VarSome's community.

Powered by Saphetor

VarSome is part of Saphetor's analysis services.

Visit Saphetor's website to find out more about the services we offer, inluding full genomic analysis, filtering, annotation, interpretation for single individuals, families and cohorts.


Saphetor is a member of the Global Alliance for Genomics & Health

Global Alliance for Genomics and Health